The objective of the present research work was to develop “once daily” extended release granules of aceclofenac by wet granulation using HPMC as a hydrophilic polymer and to check the effect of humidity on granules prepared by using different concentrations of polymer. HPMC K100M and K15M were used to check the release of drug, of which one trial showed optimum release of drug i.e. for 24 hours and were stable under accelerated conditions of temperature since there were no significant changes in drug content and physical parameters.
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